Author: Mohd. Idrees Khan, Kauser Usman, Fauzia Ashfaq, D. Himanshu, W. Ali, M.Z. Idris
Inflammatory marker high-sensitive C- reactive protein (hs-CRP) may play role as predictor of inflammation in patients with type 2 diabetes. The aim of this study was to estimate hs-CRP levels and glycemic control status and to determine association with microalbuminuria. The relationship between inflammation and microalbuminuria complications in type- 2 diabetes mellitus which has not yet been reported in North Indians. Forty two patients with microalbuminuria and twenty types-2 diabetes without microalbuminuria were enrolled. We analyzed serum concentrations of high sensitive C-reactive protein (hs-CRP), serum lipid profile, glycosylated hemoglobin and urine micro albumin levels. HbA1C and hs-CRP were significantly higher in patients with microalbuminuria diabetics cases than without microalbumiuria (p<0.0001). Furthermore, hs-CRP was poorly correlated with urinary albumin excretion (p=0.002) .This study concludes that inflammation is involved in the pathogenesis of microalbuminuria. The significance of these findings emphasizes the early detection of MAU combined with glycemic control and improved lipid profile which are fundamentals in prevention and control of diabetic complications.
Key Words: Microalbuminuria, High sensitivity-C reactive protein, Inflammation
Accepted April 03 2012
Vol - 23, Issue - 3, Jul -Sep 2012